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21.
Nazl Turan Yücel Ümmühan Kandemir Ümide Demir
zkay
zgür Devrim Can 《Molecules (Basel, Switzerland)》2021,26(11)
Vortioxetine is a multimodal antidepressant drug that affects several brain neurochemicals and has the potential to induce various pharmacological effects on the central nervous system. Therefore, we investigated the centrally mediated analgesic efficacy of this drug and the mechanisms underlying this effect. Analgesic activity of vortioxetine (5, 10 and 20 mg/kg, p.o.) was examined by tail-clip, tail-immersion and hot-plate tests. Motor performance of animals was evaluated using Rota-rod device. Time course measurements (30–180 min) showed that vortioxetine (10 and 20 mg/kg) administrations significantly increased the response latency, percent maximum possible effect and area under the curve values in all of the nociceptive tests. These data pointed out the analgesic effect of vortioxetine on central pathways carrying acute thermal and mechanical nociceptive stimuli. Vortioxetine did not alter the motor coordination of mice indicating that the analgesic activity of this drug was specific. In mechanistic studies, pre-treatments with p-chlorophenylalanine (serotonin-synthesis inhibitor), NAN-190 (serotonin 5-HT1A receptor antagonist), α-methyl-para-tyrosine (catecholamine-synthesis inhibitor), phentolamine (non-selective α-adrenoceptor blocker), and naloxone (non-selective opioid receptor blocker) antagonised the vortioxetine-induced analgesia. Obtained findings indicated that vortioxetine-induced analgesia is mediated by 5-HT1A serotonergic, α-adrenergic and opioidergic receptors, and contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this effect. 相似文献
22.
Gabriela Furlan Giordano Luis Carlos Silveira Vieira Angelo Luiz Gobbi Renato Sousa Lima Lauro Tatsuo Kubota 《Analytica chimica acta》2015
An integrated platform was developed for point-of-use determination of ethanol in sugar cane fermentation broths. Such analysis is important because ethanol reduces its fuel production efficiency by altering the alcoholic fermentation step when in excess. The custom-designed platform integrates gas diffusion separation with voltammetric detection in a single analysis module. The detector relied on a Ni(OH)2-modified electrode. It was stabilized by uniformly depositing cobalt and cadmium hydroxides as shown by XPS measurements. Such tests were in accordance with the hypothesis related to stabilization of the Ni(OH)2 structure by insertion of Co2+ and Cd2+ ions in this structure. The separation step, in turn, was based on a hydrophobic PTFE membrane, which separates the sample from receptor solution (electrolyte) where the electrodes were placed. Parameters of limit of detection and analytical sensitivity were estimated to be 0.2% v/v and 2.90 μA % (v/v)−1, respectively. Samples of fermentation broth were analyzed by both standard addition method and direct interpolation in saline medium based-analytical curve. In this case, the saline solution exhibited ionic strength similar to those of the samples intended to surpass the tonometry colligative effect of the samples over analyte concentration data by attributing the reduction in quantity of diffused ethanol vapor majorly to the electrolyte. The approach of analytical curve provided rapid, simple and accurate analysis, thus contributing for deployment of point-of-use technologies. All of the results were accurate with respect to those obtained by FTIR method at 95% confidence level. 相似文献
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在金属薄板的轴向疲劳S-N曲线测试中,研究将一种侧向防弯曲夹具应用于存在压向载荷的试验。通过粘贴应变片方法测量试样的表面应力,对试样的受力情况做了定量的分析。测量结果表明试样安装防弯曲夹具后,基本消除了由压缩失稳产生的弯曲应力。且通过对不同拧紧方式的测量,表明一定的夹紧力下不对试验力产生影响。试验夹具设计成对试样中心轴线的支撑而让边缘疲劳敏感部位处在非接触状态,试样断口表明疲劳起源在这些并没有与试样接解的部位。用钛和铝两种材料的薄板在不同试验机上进行了不同寿命和频率的试验,试验结果与正应力比试验同时给出以对比,各种研究表明本试验有效解决了薄板疲劳受压时的失稳问题。 相似文献
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利用由机械振动理论推导出的等截面简支梁的理论解,推导出了带集中质量的简支梁振动台的理论解,并通过分析动态条件下简支梁的位移与应变之间的关系,证明了:在动态条件下梁的位移与应变之间存在很好的正比关系。利用梁的位移与应变之间正比关系,如果在梁上适当位置粘贴应变片,通过测试应变就能准确地测得梁的动态位移。本文通过实例证明了该方法确实可行,理论解与实测结果非常吻合。这为简支梁的动态测试提供了有效而简便的方法。 相似文献
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4-node, 8-node and 8(4)-node quadrilateral plane isoparametric elements are used for the solution of boundary value problems in linear isotropic Cosserat elasticity. The patch test is applied to validate the finite elements. Engineering problems of stress concentration around a circular hole in plane strain condition and mechanical behaviors of heterogeneous materials with rigid inclusions and pores are computed to test the accuracy and capability of these three types of finite elements.The project supported by the National Natural Science Foundation of China (10225212, 50178016, 10421002) and the Program for Changjiang Scholars and Innovative Research Team in University of China The English text was polished by Keren Wang. 相似文献
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超声波对金属材料性能影响实验研究 总被引:4,自引:0,他引:4
通过对紫铜和低碳钢在超声波作用下材料特性的实验研究,探讨此类材料的一些特殊表现诸如屈服点降低,硬化率降低和延伸率降低等.建立了一套超声波材料拉伸实验系统,给出材料特性变化的实验数据并对这些特殊现象的形成机理进行初步探讨.给出了韧性金属材料在超声波作用下的本构方程,并与实验结果相比较,结果表明理论分析与实验结果一致 相似文献
30.
给出利用本征正交分解(POD)对屋盖风压场进行重建和预测的研究结果.对一个双坡屋盖用同步多点压力扫描系统进行了风洞试验,根据POD技术采用前若干阶本征模态重建屋盖风压场.采用两种方案预测未布置测压点位置的风压时间序列.第一种方案中利用插值技术获得没有测压点位置的本征模态值.第二种方案对参考屋盖和需预测的新屋盖分别进行试验,结合由参考屋盖试验萃取的本征模态和由新屋盖试验的风压数据计算的主坐标,预测出新屋盖未知区域的风压时间序列.文中对风压场重建和预测的效果作了分析,而且比较了根据测量的风压数据和预测的风压数据所计算的屋盖风致响应. 相似文献